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Allegra, Fexofenadine

US Brand Name Allegra
Generic Name Fexofenadine
Other Brand Name ALLEGRA, Fexigra
Packing 10
Manufacturer AVENTIS, Sanofi India
Form Tablet
Strength 30mg, 120mg, 180mg
Country India

  • 30 tab 120 mg $16.50
  • 30 tab 30 mg $7.20
  • 30 tab 180 mg $24.60
Available online
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Allegra is the trade name for the generic counterpart Fexofenadine hydrochloride, an antihistamine drug normally employed to address seasonal allergic reactions. It can be purchased upon producing prescription from your general practitioner only. Seek information from your physician before you use Allegra for your hypersensitivity reactions to ensure you select the formulation that is appropriate for you.

Fexofenadine hydrochloride is intended to alleviate the signs of hay fever (a seasonal rhinitis arising out of an allergy to pollen) and other difficulties related to allergies. These contain watery nose, sneezing and reddish and runny eyes. It is also recommended by doctors to mitigate the symptoms of urticaria. Similar to countless other drugs, Allegra poses the risk of side effects that can be detrimental to the body.

 

Mechanism of Action

 

Fexofenadine hydrochloride, the key active substance involved in terfenadine metabolism, is an antihistamine (a medicine used for allergies and hypersensitive reactions and common colds) with exclusive H1-receptor antagonist action. Both enantiomorphs of Fexofenadine hydrochloride exhibited more or less equally potent antihistaminic consequences. Allegra stamped down antigen-caused bronchospasm in allergic guinea pigs and histamine discharge from peritoneal mastocytes in rats. The medical implication of these findings is unidentified. In research lab animals, no anticholinergic or alpha1-adrenergic inhibiting results were discovered. Furthermore, no depressant or other central nervous system (CNS) upshots were found. Radiolabeled tissue circulation reports in rats suggested that Fexofenadine does not traverse the blood-brain barrier, which is a mechanism that generates blockade between brain tissues and circulating blood and helps to safeguard the central nervous system.

 

Drug Indications

 

Allegra is indicated for the alleviation of signs connected with seasonal allergic rhinitis in grownups and children more than and equal to 2 years of age. It is also indicated for treatment of unfussy skin appearances of continuing idiopathic urticaria in grownups and children who are 6 months of age and more.

 

Dosage & Administration

 

Allegra (Fexofenadine hydrochloride) medication is available in the form of tablets, orally disintegrating tablets (ODT) and oral liquid solutions. In case of seasonal allergic rhinitis and chronic idiopathic urticaria, the prescribed dosage of Allegra tablets in adults and children 12 years and more is 60 mg two times every day or 180 mg on one occasion every day with a full glass of water. A dosage of 60 mg once a day is prescribed as the introductory dose in people who are having reduced function of the kidneys.
For children from 6 to 11 Years, the prescribed dosage of Allegra tablets is 30 mg two times per day by means of water. A dosage of 30 mg one time daily is advised as the lead-in dose in paediatric patients with diminished renal or kidneys function.

Allegra ODT is specified for application solely in children from 6 to 11 years of age. So, the prescribed dosage of Allegra ODT is 30 mg two times a day for seasonal allergic rhinitis and chronic idiopathic urticaria. A dosage of 30 mg once-a-day is advocated as the initiating dose in paediatric patients having diminished renal function.

These orally disintegrating tablets are prepared to decompose on the tongue, succeeded by getting down with or without water. They must not be received empty-bellied. Allegra ODT is not meant to be masticated.  It must not be taken out from the actual blister package till the instance of administering the drug.