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Glimepiride Generic

US Brand Name Generic Amaryl
Generic Name Glimepiride
Other Brand Name Glimiprex, Euglim, GP, Glimpid, Glador, Glimulin, Glyree
Packing 10
Manufacturer Ranbaxy, Otsira Genetica, Aventis, Zydus Medica, Dr.Reddy Lab, USV, Lupin, Healtheon, Aristo Pharma, Bayer Zydus Pharma, Sun Pharma, Glenmark Pharma, Ipca Laboratories
Form Tablet
Strength 1 mg, 2 mg, 3 mg, 4 mg
Country India

  • 90 tabs 2 mg $62.10
  • 100 tabs 3 mg $85.00
  • 90 tabs 1 mg $40.50
  • 30 tabs 4mg $29.70
Available online
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Introduction

Being helpful in controlling blood sugar levels, Glimepiride helps your body respond better to insulin produced by your pancreas. Glimepiride can be used together with diet and exercise for treating patients suffering from type 2diabetes who do not take regular insulin injections. Glimepiride is a crystalline and odorless powder having a white to yellowish-white color and is available in the form of tablets for oral administration under the brand name of Generic Amaryl. Each Generic Amaryl tablet contains lactose (hydrous), sodium starch glycolate, povidone, microcrystalline cellulose, and magnesium stearate and Ferric Oxide Red.

Drug Indications

Generic Amaryl tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus which is a chronic disease associated with abnormally high levels of the sugar glucose in the blood.

Mechanism of Action

Primarily, mechanism of action of glimepiride in lowering blood glucose is dependent on the stimulation of insulin from the functioning of pancreatic beta cells. Glimepiride improves postprandial insulin/C-peptide responses and leads to overall glycemic control by leading the increased sensitivity of peripheral tissues to insulin.

Dosage & Administration

There is no fixed dosage regimen for treating diabetes mellitus with Amaryl or any other hypoglycemic agent. The dosage of these tablets are dependent on the patient's1c and the patients response to therapy should be monitored through glycosylated hemoglobin levels.

The usual starting dose of Generic Amaryl tablets are1-2 mg once daily and can be taken with breakfast or the first main meal. Sensitive patients may be given a dose of 1mg once daily and should be titrated carefully. The patient should never take more than 2 mg of these tablets in a day.

The usual maintenance dose of these tablets is 1 to 4 mg and maximum recommended dose is 8 mg. The doses should be taken once in a day. After reaching a dose of 2 mg, the dosage should be increased at intervals of 1-2 weeks basing on HbA1c levels which should be taken every 3 to 6 months, of the patient. But the increment in dosage should not be more than 2mg.

Amaryl-Metformin Combination Therapy

Metformin may be considered if patients do not respond adequately to the maximal dose of Amaryl monotherapy. By adjusting the dose of both drugs, the preferred control of blood glucose may be obtained.

Amaryl-Insulin Combination Therapy

The recommended dose of this tablet is 8 mg which should be taken once daily with the first main meal. Upward adjustments of insulin can be done after starting with low-dose insulin by frequent measurements of fasting blood glucose.

Side Effects

The side effects of Generic Amaryl tablets which are commonly seen are dizziness, asthenia, headache, nausea, vomiting, gastrointestinal pain, and diarrhea, pruritus, erythema, urticaria, morbilliform and maculopapular eruptions.

Moderately seen side effects are porphyria, photosensitivity reactions, and allergic vasculitis.

Rarely seen side effects are leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.

Side effects should be immediately reported to your doctor.

Drug Interactions

These tablets are interactive with thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, and isoniazid and may produce hyperglycemia and may lead to loss of control.

The drug significantly increased Cmax, AUC, and T½ of glimepiride with concomitant administration of propranolol.

Drug Contraindications

These tablets are contraindicated in patients who are hypersensitive to these tablets or any other component of these tablets.