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Entacapone Generic

US Brand Name Comtan
Generic Name Entacapone
Other Brand Name Entacom, Adacapone
Packing 10
Manufacturer Torrent, Sun Pharma
Form Tablet
Strength 200mg

  • 30 tabs 200 mg $17.70
Available online
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Drug Description

Generic Comtan® (entacapone) is an inhibitor of catechol-O-methyltransferase (COMT). It is a nitrocatechol-structured composite. It holds the active component of entacapone apart from the inactive ingredients such as microcrystalline cellulose, croscarmellose sodium, mannitol, hydrogenated vegetable oil, polysorbate 80, hydroxypropyl methylcellulose, glycerol 85%, magnesium stearate, sucrose, yellow iron oxide, red oxide, and titanium dioxide.


Comtan is used to treat Parkinson's disease. It is prescribed along with levodopa/carbidopa (Sinemet) to increase the effect of each dose of Sinemet. It relieves the stiffness and tremors of Parkinson's for a longer period of time. It inhibits the effect of an enzyme that breaks the levodopa in Sinemet.


Entacapone tablets should not be applied in patients who have hypersensitivity to the drug or its ingredients.

Dosage and Administration

One 200 mg tablet of Comtan (entacapone) is usually recommended to administer concurrently with each levodopa/carbidopa dose to a maximum of 8 times daily (200 mg x 8 = 1600 mg per day). The maximum daily dose should not be more than 1600 mg. The daily levodopa dose may need a reduction if it exceeds 800 mg or if patient has moderate or severe dyskinesias before beginning treatment.

Take the tablet with or without food. Caution should be applied while administering patients with impaired hepatic function. This medication should not be suddenly stopped as it may cause emergence of signs and symptoms of Parkinson's disease.

Side Effects

Use of Comtan may lead to many unwanted adverse effects. A few of such side effects are abdominal pain, constipation, back pain, diarrhea, dizziness, discoloration of urine, nausea, tired feeling, onset of new movement disorders, and vomiting.

It is advised to inform the doctor as soon as possible if the patients develop any such effects or change in intensity. Only the doctor can decide if you can continue taking this medication.

Drug Interactions

Using this medicine with certain other drugs, may increases or lessen the effects of either drug. This medication should not be taken with antidepressant drugs classified as MAO inhibitors, such as phenelzine and tranylcypromine, bitolterol, certain antibiotics, such as ampicillin and erythromycin, cholestyramine, isoproterenol, methyldopa and probenecid.


Comtan may lead to low blood pressure, with symptoms such as dizziness, fainting, nausea, and sweating. Be cautious when rising from sitting or lying condition. Observe what effect this medicine has on before driving a car or operating machinery.

Use of this drug may also lead to hallucinations, and occasional movement disorders. Some patients also experience brownish-orange color urine.

This medication should not be discontinued sudden as it can bring back Parkinson's symptoms. If you want to stop taking the drug, withdraw it slowly, under a doctor's supervision.

This drug should not be used in children. Using this drug during pregnancy may possibly harm to a developing baby. Notify your doctor right away if you are pregnant or have planning to become pregnant. Comtan may excrete in breast milk. Use it with caution if you are a nursing mother.

Over Dosage

Consequence of Comtan overdose is unknown. Nevertheless, the outcome could be serious, so if you take an overdose, ask for medical help without more ado.


Store the drug at room temperature.