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Danazol Generic

US Brand Name Generic Danocrine
Generic Name Danazol
Other Brand Name Danogen
Packing 10
Manufacturer Cipla, Aronex Life Sciences
Form Tablet
Strength 50 mg, 100 mg, 200 mg
Country India

  • 30 caps 50 mg $23.70
  • 30 caps 100 mg $32.70
  • 30 caps 200 mg $59.70
Available online
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Drug Description

Generic Danocrine is a synthetic steroid derived from ethisterone. The major component, danazol is a white to pale yellow crystalline powder, almost insoluble or insoluble in water, and thinly soluble in alcohol. Other inactive elements in this drug are lactose, corn starch, magnesium stearate, and talc. Capsules 50 mg, 100 mg and 200 mg hold fd&c red #40, D&C yellow #10, gelatin, sodium lauryl sulfate, silicon dioxide, titanium dioxide. The 50 mg and 200 mg capsules also hold D&C Red #28. The generic name of the drug is Generic Danocrine.

Drug Indications

Generic Danocrine is used to treat endometriosis, or giant hives and symptoms of fibrocystic breast disease. It reduces the level of certain hormones, which decreases the symptoms and severity of the diseases.

Dosage and Administration

Endometriosis

The recommended starting dose in moderate to severe disease or in patients infertile due to endometriosis is 800 mg given in two divided doses. The initial daily dose for amenorrhea for mild cases is 200 mg to 400 mg administered in two divided doses. The dosage may be regulated based on patient reaction.

Treatment should be commenced during menstruation. Or else, proper tests should be made to make sure that the patient is not pregnant while on treatment with this drug. Therapy may need to be continued for 3 to 6 months and may be increased to 9 months if required.

Fibrocystic Breast Disease

The total daily dosage from 100 mg to 400 mg administered in two divided doses has been recommended to treat fibrocystic breast disease. The treatment of nodularity may necessitate 4 to 6 months of uninterrupted treatment.

Hereditary Angioedema

The recommended starting dose for Hereditary Angioedema is 200 mg, two or three times a day. The dose may be reduced by 50% or less at intervals of one to three months or longer if occurrence of attacks before treatment finds. Patients may need increased daily dosage by up to 200 mg if an attack occurs.

Drug Interactions

Persistence of prothrombin time happens in patients using warfarin. Danazol may enhance carbamazepine levels in patients taking these drugs together. Danazol also should not be used with antidiabetic drugs, antihypertensive agents, cyclosporin and tacrolimus, alpha calcidol etc.

Drug Contraindications

Danocrine is contraindicated for patients with androgen-dependent tumor, undiagnosed abnormal genital bleeding, Active thrombosis or thromboembolic disease and history of such events, markedly impaired hepatic, renal, or cardiac function, pregnancy, breast feeding, porphyria and hypersensitivity to danazol.

Side Effects

Use of Generic Danocrine may bring about dizziness, fatigue, headache, appetite changes, bloating, stomach upset, or anxiety in some patients. Other side effects may also appear by using this medicine such as oily skin, flushing, weight gain, changes in sleep patterns, muscle cramps, change in sex drive, chills, fluid retention in the hands or feet or nasal congestion. Consult your doctor if any of these persist. It may also cause no or irregular menstrual periods in women.

Warning and Precautions

The use of danazol might enhance the baseline danger of ovarian cancer in patients being treated for endometriosis.

Before start taking Danocrine for fibrocystic breast disease, carcinoma of the breast must be expelled. But, pain, nodularity, tenderness caused by fibrocystic breast disease may not identify underlying carcinoma before beginning of the treatment. Hence, if any nodule continues or enlarges during cure, carcinoma should be discarded. Close monitoring of patients is required for signs of androgenic effects some.

Apply caution in patients who have diabetes mellitus.

Danocrine have caused hepatic dysfunction by modest increases in serum transaminases levels. So it is essential to perform periodic liver function tests.