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Divalproex Generic

US Brand Name Generic Depakote
Generic Name Divalproex
Other Brand Name Dicorate ER, Valance, Trend XR, Divaa
Packing 10
Manufacturer Sun Pharma, Abbott, Torrent Pharma, Intas Pharma
Form Tablet, Sustained Release Tablet
Strength 500 mg, 250 mg, 125 mg
Country India

  • 50 tabs 125 mg $9.50
  • 50 tabs 250 mg $17.50
  • 50 tabs 500 mg $34.50
  • 50 tabs 750 mg $39.50
  • 50 tabs 1000 mg $49.50
Available online
More Views
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  • Trend XR 125, Generic Depakote, Divalproex Sodium Extended Release, 125 mg, Box
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  • Divaa-125, Generic Depakote, Divalproex Sodium 125mg
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  • Divaa-125, Generic Depakote, Divalproex Sodium 125mg Tablet Strip Information
  • Divaa-125, Generic Depakote, Divalproex Sodium 125mg Box
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Introduction:

Comprised of sodium valproate and valproic acid in a 1:1 molar relationship, Divalproex sodium is a stable co-ordination compound formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. It affects the chemicals of body, which are responsible for causing seizures. Carrying the brand name of Generic Depakote, Divalproex is available in the form of tablets of strength325 mg, 250 mg, or 500 mg. The inactive components of Depakote tablets are cellulosic polymers, diacetylated monoglycerides, povidone, pregelatinized starch (contains corn starch), silica gel, talc, titanium dioxide, and vanillin.

Indication:

Generic Depakote tablets are indicated for mania, epilepsy and migraine. Mania is characterized by the pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, poor judgement, aggressiveness, and possible hostility. Epilepsy is a brain disorder in which the person has seizures which may be of two kinds, focal seizures and generalized seizures. Migraine is characterized by headaches on one or both sides of the head and is, sometimes, accompanied by nausea, vomiting.

Dosage And Administration:

Depakote tablets should be taken as directed by your physician. Amount of medicine should exceed the recommended dosage and the period of administration should not exceed the period prescribed by your doctor. Ensure plenty of fluid-intakes with this drug.

Dosage for Mania

Patients with acute manic episodes of mental disorders should be administered with an initial dosage of 750 mg of Divalproex, which should be given in divided doses. The doses should be increased rapidly so as to reach the lowest therapeutic doses which may produce 50 and 125 µg/mL of plasma concentrations. But the dosage should not exceed 60 mg/kg/day.

Dosage for Complex Partial Seizures:

The adults and children of 10 years of age or older who initiate monotherapy should be administered with an initial dosage of 10 to 15 mg/kg/day. The dosage should be increased to achieve optimal clinical response and the increments should be by 5 to 10 mg/kg/week and the daily dosage should not exceed 60 mg/kg.

The adults and children of 10 years of age or older who initiate conversion to monotherapy, should be given a dosage of 10 to 15 mg/kg/day, at first, and then the dosage should be increased by 5 to 10 mg/kg/week but should not exceed 60 mg/kg/day.

The recommended initial dosage for adults and children of 10 years of age or older who initiate adjunctive therapy is10 to 15 mg/kg/day. The daily dosage should not exceed 60 mg/kg/day even though an increment of 5 to 10 mg/kg/week may be done to achieve the desired response.

In case of simple and complex absence seizures, the patients may be given a starting dose of 15 mg/kg/day which should be increased at one week interval by 5 to 10 mg/kg/day until seizures are controlled. The daily dosage given should be in divided doses if the daily dose exceeds 250mg per day. The maximum daily dosage is of 60 mg/kg/day.

Overdose

In case you have used overdose, make contact with your local poison control center without delay.

Missed Dose

If you seem to miss a dose, take it immediately you remember. But you should not take double dose to make up the missed dose.

Side Effects:

The most common side effects of Generic Depakote tablets are nausea, somnolence, dizziness, vomiting, asthenia, abdominal pain, dyspepsia, rash, chest pain, chills, chills and fever, neck pain and neck rigidity.

Other side effects of Divalproex tablets may include hypertension, hypotension, palpitations, postural hypotension, tachycardia, vasodilation, anorexia, fecal incontinence, flatulence, gastroenteritis, glossitis, periodontal abscess, ecchymosis, edema, peripheral edema, arthralgia, arthrosis, leg cramps, twitching, abnormal dreams, abnormal gait, agitation, ataxia, catatonic reaction, confusion, depression, diplopia, dysarthria, hallucinations, hypertonia, hypokinesia, insomnia, paresthesia, reflexes increased, tardive dyskinesia, thinking abnormalities and vertigo.

Drug Interaction

This drug can possibly interact with many other medicines. Some of these drugs that may cause drug interactions are: amitriptyline (Elavil®), carbamazepine (epitol®, tegretol®, equetro™, tegretol xr®), aspirin, carbapenem antibiotics, Diazepam (Valium®), Clonazepam (Klonopin®) , Ethosuximide (Zarontin®), Lamotrigine (Lamictal®), Felbamate (Felbatol®), Phenobarbital (Luminal®) and Nortriptyline (Pamelor®) and many other drugs.

Storage:

Store Divalproex tablets away from direct heat and light. Keep in a cool dry place, away from the reach of children and pets.