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Alendronate Generic

US Brand Name Generic Fosamax
Generic Name Alendronate
Other Brand Name Osteofos
Packing 10, 4
Manufacturer Cipla
Form Tablet
Strength 10mg, 35mg, 70mg
Country India

  • 4 tab 35mg $7.90
  • 4 tab 70mg $9.90
Available online
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Alendronate (Generic Fosamax)

Alendronate is the generic form of the osteoporosis drug Fosamax. It is used mostly in treatment of post-menopausal women with osteoporosis. It has been shown to increase bone mineral density in the wrist, hip, and spine. In a clinical study, patients treated with Alendronate, plus calcium and vitamin D experienced far fewer fractures than those only taking calcium and vitamin D. This drug can be used in women in men, and it can be used as a preventive measure.

In 2008, the pharmaceutical company Merck lost its appeal to block the marketing of a generic from receiving FDA certification. Generics are now available in dosages of 5 mg, 10 mg, and 40 mg for daily use, and in 35 mg and 70 mg forms that are taken once a week.

Alendronate should not be used by people with inflammation of the digestive tract, people with rickets (a disease of bone de-mineralization caused by lack of vitamin D), malformations of the esophagus, the inability to sit upright, stand, or walk for 30 minutes after ingestion, or impaired kidney function. It should also not be used by women who are pregnant or breastfeeding, or by people younger than age 18 because no clinical data exists for people under 18.

To take alendronate properly, take the tablet and swallow with water, then swallow water two more times. It is important not to drink more than 8 oz of water with alendronate. After taking the drug, stand, walk, or sit for 30 to 45 minutes before eating breakfast. Gastroesophageal reflux and irritation can occur if you lie down or recline before eating breakfast. It is important that you allow at least 30 minutes to elapse before meals or other beverages are taken.

Side effects have been reported by people taking alendronate that include skin rash, skin infection, eye inflammation, bodily pain, ulceration of the esophagus or duodenum, deterioration of the temporomadibular joint in patients having dental work of any kind, visual and auditory disturbances, and changes in bone composition including increased numbers of osteoclasts.

Alendronate interacts with milk and drugs and food that are high in calcium, magnesium, or aluminum. If alendronate is taken with or soon after these foods or milk, the drug is not absorbed properly. For that reason, patients should wait at least 30 minutes after taking alendronate before drinking milk or taking supplements or drugs with calcium, magnesium, or aluminum.

Because no data are available on the effects of alendronate with use of fluoride or highly active vitamin D, it is advisable for patients not to combine these therapies. There is also no clear data as to whether hormone replacement therapy with estrogen, progestins, or raloxifene has any interaction with alendronate. When combined with alendronate, non-steroidal anti-inflammatory drugs may increase the risk of gastric ulcers, because both types of drugs can irritate the upper digestive tract mucosa.

A letter published in the New England Journal of Medicine in 2008 referred to a finding by the FDA that 23 cases of esophageal cancer had possible links to alendronate since the introduction of Fosamax in 1995. Other cancer patients have experienced osteonecrosis of the jaw if they take alendronate at the same time with IV bisphopshonates Aredia or Zometa.