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Glibenclamide Generic

US Brand Name Glyburide
Generic Name Glibenclamide
Other Brand Name Glybovin, Daonil, Semi-Daonil, Euglucon
Packing 10
Manufacturer Aventis, Otsira Genetica, Aristo Pharma, Emcure Pharma, Abbott
Form Tablet
Strength 5 mg, 2.5 mg
Country India

  • 100 tabs 5 mg $29.00
  • 100 tabs 1.25 mg $23.00
Available online
More Views
  • Semi Daonil, Generic  Glyburide, Glibenclamide 2.5 mg Tablet (Otsira Genetica)
  • Semi Daonil, Generic Glyburide,  Glibenclamide 2.5 Mg Tablet (Otsira Genetica)
  • Semi Daonil, Generic Glyburide,  Glibenclamide 2.5 Mg Tablet (Otsira Genetica)
  • Semi Daonil, Generic  Glyburide,  Glibenclamide  Tablet
  • Semidaonil, Generic Glyburide, Glibenclamide Information Sheet 1
  • Semidaonil, Generic Glyburide, Glibenclamide Information Sheet 2
  • Semidaonil, Generic Glyburide, Glibenclamide Information Sheet 3
  • Semidaonil, Generic Glyburide, Glibenclamide Information Sheet 4
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Glyburide is a drug belonging to the sulfonylurea class. This drug is a white, crystalline composite offered as tablets with dosage strength of 1.25 mg, 2.5 mg, and 5 mg. The active component of the tablets is Glibenclamide. This blood-glucose-lowering medication is meant for oral administration.


Indication


Generic Glyburide is indicated for treatment of Insulin-dependent type 2 Diabetes with partly preserved synthesis of insulin.

Contraindications

This drug is contraindicated in patients with diabetic ketoacidosis; during pregnancy. This medication also should be avoided in patients having serious renal and liver dysfunction; and registered individual hypersensitivity to this drug.

Dosage and Administration


A dose of 2.5 to 5 mg daily has been approved as starting dose. The drug should be taken with breakfast or the first main meal. Patients who have more sensitivity to hypoglycemic drugs can start at 1.25 mg daily.


Some Type II diabetic patients treated with insulin show good response to Glyburide. If the insulin intake is less than 20 units daily, this drug can be taken at 2.5 to 5 mg as a single daily dose. If the insulin dose ranges between 20 and 40 units daily, the patient can take 5 mg daily of this medicine as a single dose. If the insulin dose is higher than 40 units daily, it needs a change period for conversion to Glyburide.


A dose from 1.25 to 20 mg daily has been recommended as the usual maintenance dose. The dosage may be taken as a single dose or in divided doses. Dosage needs to be enhanced no more than 2.5 mg at weekly intervals based upon the patient's response. The dose can be taken as maximum as 20 mg.

Side Effects

Side effects can't be ignored altogether. This drug may bring about many mild as well as complicated adverse reactions. Allergic reaction is the frequent adverse reaction caused by using this drug. Hence you should discontinue using it and seek for medical notice if any of these adverse effects take place: closing of the throat; breathing difficulty; swelling of lip, tongue; or hives.

Side effects from Glyburide also may comprise changed blood sugar levels. It may be too high or too low. If this medication is taken in higher amount, it may cause low blood sugar level. The lower blood sugar may also cause if other drugs are taken; during illness, particularly with vomiting or diarrhea or after drinking alcohol.

Drug Interactions


Before being treated with Glyburide, you must tell your doctor or pharmacist if you are already taking any medicines. Also you should talk to your doctor or pharmacist before taking any new drug while being treated with Glyburide. Glibenclamid may enhance the hypoglycemic effect if taken with H2-blockers, β-blockers, sulphonamides, tetracycline, cumarin derivatives, clofibrate, salicylates, chloramphenicol, and MAO-inhibitors.

Anticoagulant effect of warfarin is increased by Glibenclamid. Glibenclamid's effectiveness may be decreased if used with estrogen, Corticosteroids, and gestegen hormones, oral contraceptives and phenothiazines.

Precautions

All sulfonylurea drugs may lead to severe hypoglycemia. Hence appropriate dosage and instructions should be followed to keep away from hypoglycemic episodes. Renal or hepatic insufficiency is more likely to increase hypoglycemia conditions. Elderly, malnourished patients, adrenal or pituitary insufficient patients are at higher risk to develop hypoglycemic action.

Concomitant use of glucose 6-phosphate dehydrogenase (G6PD) deficiency with sulfonylurea agents can cause hemolytic anemia. Since Glibenclamid is a sulfonylurea agent, you should apply necessary caution in patients with G6PD deficiency. Here the patient can consider a non-sulfonylurea alternative.

The patients should undergo periodic fasting blood glucose measurements to check therapeutic response. It is essential to make a glycosylated hemoglobin determination from time to time.

Elderly patients with hepatic and renal failure need extra care with this drug.