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Acarbose Generic

US Brand Name Precose
Generic Name Acarbose
Other Brand Name Asucrose, Rebose
Packing 10
Manufacturer MerindWockhardt, Sun Pharma
Form Tablet
Strength 25mg, 50mg
Country India

  • 50 tabs 25 mg $19.50
  • 50 tabs 50 mg $30.50
Available online
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Introduction

In human body, there are certain kinds of enzymes who turn carbohydrates into glucose. Acarbose is a drug available under prescription for slowing down the action of these enzymes. Being a glucosidase inhibitor, Acarbose is used for the treatment of patients suffering from type 2 diabetes for decreasing blood sugar levels. It may be taken along with diet and exercise. Having a pKa of 5.1, Acarbose is a powder of white to off-white color and is soluble in water. Carrying the brand name of Generic Precose, it is available in the form of tablets in the strength of 100 mg to be taken orally.

Drug Indications

Acarbose is an oligosaccharide and is obtained from fermentation processes of a microorganism called actinoplanes utahensis. Generic Precose tablets are indicated for improving glycemic control in adults with type 2 diabetes mellitus and are followed as an adjunct to diet and exercise.

Mechanism of Action

Acarbose results in the inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes which hydrolyze complex starches to oligosaccharides in the lumen of the small intestine and oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine, respectively. The inhibition of these enzymes results in lowering of postprandial hyperglycemia by delaying glucose absorption.

Dosage & Administration

Initial Dosage

A dose of 25 mg of Generic Precose tablets may be initially administered three times in a day. In order to minimize gastrointestinal side effects, some patients may be administered with a relatively smaller dose of 25mg in a day taken once and gradual increase in the dosage may be done to 25mg taken twice in a day.

Maintenance Dosage

Basing on the one-hour postprandial glucose or glycosylated hemoglobin levels and tolerance, the dosage of Generic Precose tablets should be done but only after reaching the dosage regimen of 25 mg t.i.d at an interval of 4-8 weeks. The dosage can be increased to 50 mg t.i.d. from 25 mg t.i.d. A dose of 100 mg t.i.d. may be required by some patients. The maintenance dosage of these tablets range from 50 mg t.i.d. to 100 mg t.i.d.

Maximum Dosage

Patients having a body weight lesser equal to 60 kg should not be administered with a dose more than 50 mg t.i.d. and the patients having a body weight more than 60 kg should not be administered with a dose more than 100 mg t.i.d.

Side Effects

Generally, symptoms of abdominal pain, diarrhea, and flatulence have been observed as side effects of these tablets. An elevation in serum transaminase levels have been noticed as a side effect to the consumption of this drug.

The most common side effects of Generic Precose tablets are hypersensitive skin reactions like rash, erythema, exanthema and urticaria, edema, ileus/subileus, jaundice and/or hepatitis and associated liver damage. Side effects should be immediately reported to your doctor.

Drug Interactions

Drugs categorized as thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel- blocking drugs, and isoniazid interact with Acarbose leading to hyperglycemia.

Appropriate adjustment in the dosage of this drug should be done if it is taken with sulfonylurea agents or insulin, otherwise hypoglycemia may result.

Drug Contraindications

Patients with diabetic ketoacidosis or cirrhosis, inflammatory bowel disease, colonic ulceration and partial intestinal obstruction are contradicted from taking these tablets. Patients with chronic intestinal diseases associated with marked disorders of digestion or absorption and patients who have conditions that may get worse as a result of increased gas formation in the intestine should not take these tablets. Those who are hypersensitive to this drug or any of the ingredients of the drug should not take these tablets.