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Labetolol Generic

US Brand Name Normodyne; Trandate;
Generic Name Labetolol
Other Brand Name Lobet, Alphadopa L
Packing 10
Manufacturer Samarth Life Sciences, Wockhardt
Form tablet
Strength 100 mg
Country India

  • 50 tabs 100 mg $46.60
Available online
More Views
  • Lobet, Labetalol box
  • Alphadopa L, Labetalol box

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Introduction

Categorized under the group of drugs called beta-blockers, the Labetalol affects the heart and blood circulation (blood flow through arteries and veins). This drug is available under prescription and is prescribed for patients suffering from high blood pressure. Containing adrenergic receptor blocking agents that have both selective alpha1-adrenergic and nonselective beta-adrenergic receptor blocking actions in a single substance, it is prescribed either alone or with other drugs. It is very much effective with thiazide and loop diuretics. Labetalol is indicated for oral administration and comes in the form of tablets carrying the trade name of Generic Normodyne. Each Labetalol tablet contains titanium dioxide, talc, sodium benzoate, pregelatinized corn starch, magnesium stearate, lactose, hydroxypropyl methylcellulose and corn starch.

Drug Indications

Generic Normodyne tablets are indicated for managing hypertension in patients. These tablets can be used with other antihypertensive agents, especially thiazide and loop diuretics, or may be administered alone for treating high blood pressure.

Dosage & Administration

Strict directions of your physician should be followed regarding the dosage of Generic Normodyne tablets or the instructions on the medicine strip may be followed. These dosages are dependent on the response shown by the patient. The patients may be given a dose of 100mg twice in a day. The dosage may be increased after two to three days by 100mg till 400mg twice in a day. Patients who are suffering from severe hypertension, prescribed with or without thiazide diuretics, may need dosage of 1,200 to 2,400 mg in a day. Generally, the recommended dosage for elderly persons is 100 mg twice daily and should be gradually increased to 200mg b.i.d.

Side Effects

The side effects, in descending order of severity, of Generic Normodyne tablets are vertigo, vision abnormality, rash, respiratory dyspnea, bradycardia, postural hypotension, edema, increased sweating, impotence, ejaculation failure, nasal stuffiness, drowsiness, paresthesia, dizziness, taste distortion, diarrhea, abdominal pain, dyspepsia, vomiting, nausea, headache, asthenia and fatigue.

Rare cases of hypersensitivity and anaphylactoid reactions are reported as side effects of these tablets.

Drug Interactions

Concomitant usage of Generic Normodyne tablets with antidepressants leads to tremor. Labetalol tablets are interactive with drugs possessing beta-blocking properties affects the bronchodilator effect of beta-receptor agonist drugs in patients suffering from bronchospasm. Cimetidine accelerates the bioavailability of labetalol hydrochloride. Hypotensive anesthesia with this drug may increase the degree of hypotension due to the possibility of a large reduction in cardiac output and an increase in central venous pressure. Calcium antagonists of the verapamil type should be carefully administered along with this drug. The antihypertensive effects of the drug may increase with nitroglycerin.

Drug Contraindications

Patients with a history of obstructive airway disease, including asthma, should not be administered with beta blockers with or without cardioselectivity. Labetalol tablets are contraindicated in patients who are suffering from bronchial asthma, overt cardiac failure and greater-than-first-degree heart block. Individuals with cardiogenic shock, severe bradycardia and other conditions which are associated with severe and prolonged hypotension should not take these tablets. Individuals who are hypersensitive of these tablets, titanium dioxide, talc, sodium benzoate, magnesium stearate, lactose, hydroxypropyl methylcellulose or any other component of these tablets should avoid these tablets.