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Ezetimibe Generic

US Brand Name Zetia
Generic Name Ezetimibe
Other Brand Name Ezentia, Ezedoc
Packing 10
Manufacturer Sun pharma, Lupin
Form Tablet
Strength 10mg
Country India

  • 30 tabs 10mg $20.70
Available online
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Introduction

Ezetimibe helps in reducing the amount of cholesterol absorbed by the body and is used for treatment of patients suffering from high blood cholesterol. It is a crystalline powder having a white color and free solubility with ethanol, methanol and acetone and is practical insoluble with water. Having a melting point of about163°C, it is stable at ambient temperature. Being intended for oral administration, it comes in the form of tablets under the brand name of Generic Zetia. Along with Ezetimibe, the Zetia tablet is composed of many other inactive ingredients.

Drug Indications

The Zetia tablets are indicated for high blood cholesterol. They reduce the bad cholesterol which is responsible for the promotion of clogged arteries, which increase the risk of heart attack and stroke and increase the good cholesterol which helps to prevent clogged arteries. They are also used as a combined therapy with Statins and with Fenofibrate.

Drug Action

By inhibiting the absorption of cholesterol, Ezetimibe reduces blood cholesterol. It is localized at the brush border of the small intestine and reduces the delivery of intestinal cholesterol to the liver thereby causing a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. It does not impair adrenocortical steroid hormone production as its effect on fat soluble vitamins is fatal.

Dosage & Administration

The Ezetimibe tablets should be taken as per the direction of the doctor. It should not be taken more than the period prescribed for. Any change in the dosage should be done only after obtaining the permission of the physician. These tablets can be taken empty stomach or with food. During its mono therapy, the recommended normal dosage is of 10 mg per day. During combined therapies, the dosages of this drug may be needed to be adjusted.

Side Effects

The possible adverse reactions of Ezetimibe tablets include the hypersensitivity reactions even including symptoms of anaphylaxis, angioedema, rash, and urticaria. In some cases, erythema multiforme, arthralgia, myalgia, elevated creatine phosphokinase have been observed as the side effects to the consumption of this drug.

Other additional side effects of this drug are hepatitis, pancreatitis, dizziness, abdominal pain, myopathy/rhabdomyolysis, head-ache, cholecystitis, elevations in liver transaminases, depression, thrombocytopenia, nausea, paresthesia and cholelithiasis.

In some cases, arthralgia, pain in extremity, diarrhea and sinusitis have been reported as side effects of Zetia tablets.

Drug Interactions

Cyclosporin and fibrate are interactive with Ezetimibe. Concomitant consumption of Zetia tablets with cyclosporine leads to alterations in lipid levels, and with fibrate leads to cholelithiasis which is caused due to increase cholesterol excretion into the bile.

Drug Contradictions

The consumption of Zetia tablets is contraindicated with patients having active liver disease, pregnant women if they are consuming medicines like statins, nursing mothers as there are possibilities of the drug to be passed into breast milk and individuals having hypersensitivity to any component of these tablets.

How to Store

The Zetia tablets can be stored at room temperature. They should be kept in cool dry place, away from the reach of children and pets. Contact with direct heat and light should be avoided. Keep away from moisture.