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Clopidogrel Generic

US Brand Name Plavix
Generic Name Clopidogrel
Other Brand Name Clopivas, Plopicard, Bio-Clopi, Deplatt
Packing 4, 10
Manufacturer Dr Reddy, Sava medica, Novartis India, Cipla, Torrent Pharma, Okasa, Intas Pharma
Form Tablet
Strength 75 mg, 300mg
Country India

  • 30 tabs 75 mg $20.80
  • 4 tabs 300 mg $3.70
Available online
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Introduction:

Clopidogrel helps the platelets in blood from coagulating (clotting) and thus, prevent unwanted blood clots that occur due to certain heart or blood vessel conditions. It is a powder having a white to off white color and is freely soluble with pH 1, neutrally soluble with pH and insoluble with water. It has a practical insolubility with ethyl ether and a ready solubility with methanol and a sparing solubility with methylene chloride.

Under the brand name of Plavix Generic, Clopidogrel comes in the form of tablets to be taken in by mouth. Plavix tablets, being inhibitors of ADP, inhibit adenosine diphosphate and induce platelet aggregation to bind to its receptor and to the subsequent ADP-mediated activation of the glycoprotein.

Indication:

The Plavix Generic tablets are indicated for the treatment of patients who have recently faced myocardial infarction or heart stroke or are suffering from established peripheral arterial disease and acute coronary syndrome.

Mechanism Of Action:

Clopidogrel acts as an inhibitor of platelet aggregation and decrease the chances of forming of blood clots by preventing the platelets from coagulating. People with established cardiovascular atherosclerotic disease who have suffered from the events like stroke or transient ischemic attacks, myocardial infarction, unstable angina or the persons who have undergone vascular bypass or angioplasty have shown favorable results of this medication, there by indicating that the inhibiting platelet function can reduce the event rate.

Dosage And Administration:

The recommended daily dose of Plavix for patients, who have faced recent myocardial infarction, recent stroke, or established peripheral arterial disease, is 75 mg per day and this should be administered once in a day as a single dose.

An initial loaded dose of 300-mg should be administered to the patients suffering from acute coronary syndrome with non-ST-segment elevation, and then they may be administered with a regular daily dose of 75 mg which should be taken as a single dose. These patients should not only be administered with Clopidogrel alone but along with it they should be given a dosage of 75 mg-325 mg once daily of Aspirin.

For patients with ST-segment elevation acute myocardial infarction should also be administered with Aspirin along with Clopidogrel tablets. The recommended usual dosage is of 75 mg once daily. A loading dose of 300 mg may or may not be administered to the patients.

Overdose

In case you have used overdose, make contact with your local poison control center without delay.

Missed Dose

If you seem to miss a dose, take it immediately you remember. But you should not take double dose to make up the missed dose.

Side Effects:

Side effects, severe or fatal, are always associated with all kinds of medications, and the Plavix Generic is no exception to it. Whatever the side effects of a drug may be, their persistence should be reported to your doctor.

The possible side effects of Clopidogrel tablets are hypersensitivity reactions, anaphylactoid reactions, serum sickness. Symptoms of confusion, hallucinations, taste disorders, abnormal liver function test, hepatitis (non-infectious), acute liver failure cases of bleeding with intracranial, gastrointestinal and retroperitoneal hemorrhage have been observed in some patients as the side effects due the consumption of the drug.

Additional side effects, which are rare but are more adverse in characters are thrombotic thrombocytopenic purpura, agranulocytosis, aplastic anemia/pancytopenia, conjunctival, ocular and retinal bleeding, bronchospasm, interstitial pneumonitis, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, lichen planus, glomerulopathy, increased creatinine levels, vasculitis, hypotension and myalgia.

Drug Interaction:

Clopidogrel is interactive with omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and ticlopidine. So their concomitant usage should be avoided. It should be carefully administered with nonsteroidal anti-inflammatory drugs (NSAIDS) and warfarin.

Storage:

These tablets can be stored at room temperature but their exposal to direct heat and light should be avoided. Keep away from children and pets.