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Nabumetone Generic

US Brand Name Generic Relafen
Generic Name Nabumetone
Other Brand Name Nilitis
Packing 10
Manufacturer Ipca Laboratories
Form Tablet
Strength 500 mg
Country India

  • 28 tabs 500 mg $22.12
Available online
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Introduction:

Falling under the group of anti-inflammatory drugs, Nabumetone is helpful in reducing inflammation and pain in the body caused by arthritis and works by reducing the hormones that cause these. By blocking certain substances in the body that are responsible for causing inflammation, the drug treats the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms. Nabumetone is a crystalline substance of white to off-white color and has a molecular weight of 228.3. It is nonacidic and is soluble in alcohol and most organic solvents but is insoluble in water. Carrying the brand name of Generic Relafen, it is available for oral administration in the form of tablets. Hypromellose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium lauryl sulfate, sodium starch glycolate, and titanium dioxide are the inactive components of these tablets.

By blocking certain substances in the body that are responsible for causing inflammation, the NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Indication:

Generic Relafen tablets are indicated for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. Osteoarthritis is a kind of arthritis that is caused due to inflammation, breakdown, and eventual loss of cartilage in the joints. It is also called as degenerative arthritis. Rheumatoid arthritis is an autoimmune disease in which chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body is caused.

Dosage And Administration:

The dosage of the Generic Relafen tablets varies from person to person. It is dependent on the response of the patient to the drug.

Patients suffering from osteoarthritis and rheumatoid arthritis should be administered a dose of 1,000 mg as a single dose with or without food. Serious patients may be administered with a higher dose of 1,500 mg to 2,000 mg per day either as a single dose or as divided into two doses. Chronic patients should be treated with the lowest effective dose. Most probably patients having a body weight of less than 50kg may require dose less than of 1000mg per day.

But the dose should not exceed 2000mg per day as proper studies regarding this dose have not so far been conducted.

Side Effects:

The side effects of Generic Relafen tablets which are seen at varied frequencies are anaphylactoid reaction, anaphylaxis, angioneurotic edema, thrombocytopenia, albuminuria, azotemia, hyperuricemia, interstitial nephritis, nephrotic syndrome, vaginal bleeding, renal failure, dyspnea, eosinophilic pneumonia, hypersensitivity pneumonitis, idiopathic interstitial pneumonitis, bullous eruptions, photosensitivity, urticaria, pseudoporphyria cutanea tarda, toxic epidermal necrolysis, erythema multiforme, stevens-johnson syndrome.

On experiencing any of the above stated side effects, immediate assistance of a doctor should be sought for.

Drug Interaction:

Generic Relafen tablets are interactive with ACE-inhibitors and diminish their antihypertensive effect. Even though aspirin does not affect the clearance of the drug yet its protein binding is reduced due to the drug. The natriuretic effect of furosemide and thiazides is reduced due to Nabumetone. It leads a fall in renal lithium clearance.

Drug Contraindication:

Generic Relafen tablets are contraindicated in patients who have developed any kind of hypersensitivity to Nabumetone or any other content of these tablets. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs should not be given these tablets. These tablets are contradicted with those patients who are receiving treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.