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US Brand Name Generic Colospa
Generic Name Mebeverine
Other Brand Name Morease
Packing 10
Manufacturer Dr Reddy's Laboratories
Form Tablet
Strength 135mg
Country India

  • 50 tabs 135mg $31.50
Available online
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Mebeverine acts directly on the smooth muscle in the gut causing it to relax. It also prevents nerve signals getting through to the muscle in the intestines. This also causes the muscle to relax, preventing painful muscle spasm.


Mebeverine is a musculotropic antispasmodic drug and has no atropic side-effects. Being registered in 1965, this drug is available under prescription for oral administration. Under the brand name of Colospa, the drug is available in the strength of 135 mg, in the form of tablets to be taken by mouth and is used for treating organic disorder as well as gastrointestinal spasm. It is also available under the brands named as Colofac, Duspatal and Duspatalin by Solvay Pharmaceuticals.


Mebeverine tablets are indicated for treatment of spastic functional disturbances of the colon like the irritable bowel syndrome in its primary form as well as irritable bowel syndrome associated with organic lesions of the gastrointestinal tract including diverticulosis and diverticulitis, regional enteritis, disease of the gall bladder and gall ducts, gastric and duodenal ulcers, dysentery, and aspecific or specific inflammation of the digestive tract.

Mechanism Of Action:

Belonging to the group of compounds called musculotropic antispasmodics, Mebeverine is an antimuscarinic and acts directly on the gut muscles at the cellular level to relax them. And because it is also an inhibitor of calcium-depot replenishment, it has dual mode of action for normalizing the small bowel motility.

Dosage And Administration:

For the dosage, you can talk to your doctor or you may refer to the instructions for dosage that come on the medicine strip. The pharmacy label on your medicine reveals the usage and dosage of the medicine. Generally, these tablets are to be taken empty stomach, so you can take these tablets nearly 20 minutes before meals. The dosage for adults, children and elderly persons are different, depending on their response to the medicine. The dosage instructions should strictly be adhered to for getting best results and avoiding unnecessary health problems which may arise out of the wrong dosing of the medicine. You can change the dose of the medicine only on obtaining the permission of your doctor.

Side Effects:

The side effects which are commonly associated with Mebeverine are urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombopenia or angioedema. Some cases have revealed inflamed or reddened skin, itching or skin rashes as side effects of the drug. Very rare cases have shown up swelling of the face, lips and/or tongue leading to the discontinuation of treatment with the drug.

Drug Interaction:

Any interaction of the Colospa tablets with other drugs or any laboratory results have not yet been brought under notice but if you experience any unusual symptoms while taking these tablets, you should let your doctor know about the same.


Colospa tablets are contraindicated with patients who have developed any kind of hypersensitivity towards Mebeverine or any other component of these tablets. These tablets are also contraindicated with patients suffering from paralytic ileus and porphyria.


These tablets should be stored in a dry, cool place but should not in a freezer. These can be stored at room temperature. Avoid their contact with moisture and direct heat and light. Keep medicines out of reach of your children and pets.