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Tracrium, Atracurium Besylate

US Brand Name Tracrium
Generic Name Atracurium Besylate
Other Brand Name Tracrium, Artacil, Atrelax
Packing 2.5 ml
Manufacturer Noon Labs, Changra, GSK
Form Amp, Injection
Strength 10 mg/ml
Country India

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  • Tracrium, Atracurium Besylate 2.5 ml  Injection

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  • Generic Tracrium, Atracurium Injection

    Generic Name: Atracurium Besylate
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Atracurium Besylate injection under the trade name Tracrium has been approved for use as an intermediate-duration muscle relaxing agent. It is applied as an adjunct to general anesthesia at the time of surgical procedure or mechanical ventilation or breathing.

Mechanism of Action

Tracrium (Atracurium) can be defined as a non-depolarizing, intermediate-length, and skeletal neuromuscular blocking agent (a substance that creates obstacles in the neural transmission between motor neurons and skeletal muscles). Non-depolarizing agents counteract the neurochemical activity of acetylcholine (a derivative of choline) by adhering aggressively to cholinergic receptor locations on the motor end plate (the flattened end of a motor neuron). This antagonizing act is suppressed and neuromuscular block overturned by acetylcholinesterase inhibitors, for instance neostigmine (trade name Prostigmin), edrophonium and pyridostigmine.

The period of neuromuscular hindrance generated by Atracurium is more or less one-third to one-half the period witnessed with d-tubocurarine, metocurine and pancuronium at dosages having equal strength or efficacy. As happened with other non-depolarizing neuromuscular blocking agents, the time to oncoming of paralysis diminishes and the length of utmost effect rises with rising Tracrium (Atracurium) doses.


The pharmacology or pharmacokinetics of Tracrium in human being is basically linear inside the 0.3 to 0.6 mg/kg range of doses. The excretion half-life is around 20 minutes. The period of neuromuscular obstruction brought forth by Atracurium does not show a relationship with plasma pseudocholinesterase levels and is not varied by the nonexistence of kidney-related function.

Indication & Usage

Tracrium is clinically indicated as an add-on to general anesthesia. In addition, it is also used to smooth the progress of endotracheal intubation and to offer skeletal muscle repose throughout surgery or external respiration through a ventilator. It can be employed most beneficially if muscle spasm reaction to peripheral nerve stimulation is observed.


Atracurium must be applied solely by those individuals who are experienced in the administration of ventilation and simply when amenities are readily accessible for endotracheal intubation and for supplying sufficient external respiration of the patient, including the management of oxygen below positive pressure and the removal of carbon dioxide. The practitioner should be ready to aid or manage ventilation and anticholinesterase reversal agents must be right away on hand. Do not administer Atracurium in an intramuscular way.

Tracrium has no acknowledged outcome on consciousness, pain threshold (the lowest amount of stimulation at which pain is felt) or thought process. It must be employed only with enough anesthesia.

The Atracurium injection that features an acid pH must not be combined with alkaline solutions (for example, sedative-hypnotic solutions) in the same syringe or dispensed at the same time during intravenous infusion by the unchanged needle. In such mixes, the consequential pH may induce deactivation of the medication and precipitation of the detached acid.

Tracrium (Atracurium) 10 mL multiple-dose ampoules have benzyl alcohol. Benzyl alcohol has been connected to an elevated occurrence of neurological and other difficulties in newborn babies which are at times deadly. However, the 5 mL ampoules do not have the presence of benzyl alcohol.